Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim

• Main Authors: Sumit Basu (Author), Yi Ting (Kayla) (Author), Valvanera Vozmediano (Author), Jan-Frederik Schlender (Author), Thomas Eissing (Author), Stephan Schmidt (Author), Christoph Niederalt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Physiologically based pharmacokinetic (PBPK) models are increasingly used to support pediatric dose selection for small molecule drugs. In contrast, only a few pediatric PBPK models for therapeutic antibodies have been published recently, and the knowledge on the maturation of the processes relevant...