Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim

• Κύριοι συγγραφείς: Sumit Basu (Συγγραφέας), Yi Ting (Kayla) (Συγγραφέας), Valvanera Vozmediano (Συγγραφέας), Jan-Frederik Schlender (Συγγραφέας), Thomas Eissing (Συγγραφέας), Stephan Schmidt (Συγγραφέας), Christoph Niederalt (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Physiologically based pharmacokinetic (PBPK) models are increasingly used to support pediatric dose selection for small molecule drugs. In contrast, only a few pediatric PBPK models for therapeutic antibodies have been published recently, and the knowledge on the maturation of the processes relevant...