Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Pediatric Populations Using PK-Sim

• প্রধান লেখক: Sumit Basu (লেখক), Yi Ting (Kayla) (লেখক), Valvanera Vozmediano (লেখক), Jan-Frederik Schlender (লেখক), Thomas Eissing (লেখক), Stephan Schmidt (লেখক), Christoph Niederalt (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Physiologically based pharmacokinetic (PBPK) models are increasingly used to support pediatric dose selection for small molecule drugs. In contrast, only a few pediatric PBPK models for therapeutic antibodies have been published recently, and the knowledge on the maturation of the processes relevant...