Monocrotaline-mediated autophagy via inhibiting PI3K/AKT/mTOR pathway induces apoptosis in rat hepatocytes

• Main Authors: Yazhou Guo (Author), Yang Yuan (Author), Ruibo Wang (Author), Jun Bai (Author), Yanqing Jia (Author), Xinxin Qiu (Author), Huafeng Niu (Author), Long Li (Author), Yan Luo (Author), Baoyu Zhao (Author), Zhencang Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monocrotaline (MCT), a major pyrrolizidine alkaloid, is well-known for its high liver toxicity. Dysregulation of autophagy induced apoptosis can lead to various liver diseases, including those induced by chemical compounds. Therefore, we aim to explore whether autophagy might serve as a potential st...