Monocrotaline-mediated autophagy via inhibiting PI3K/AKT/mTOR pathway induces apoptosis in rat hepatocytes

• Главные авторы: Yazhou Guo (Автор), Yang Yuan (Автор), Ruibo Wang (Автор), Jun Bai (Автор), Yanqing Jia (Автор), Xinxin Qiu (Автор), Huafeng Niu (Автор), Long Li (Автор), Yan Luo (Автор), Baoyu Zhao (Автор), Zhencang Zhang (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Предметы: article
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Monocrotaline (MCT), a major pyrrolizidine alkaloid, is well-known for its high liver toxicity. Dysregulation of autophagy induced apoptosis can lead to various liver diseases, including those induced by chemical compounds. Therefore, we aim to explore whether autophagy might serve as a potential st...