Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model

• Main Authors: Leonor Côrte-Real (Author), Ana Rita Brás (Author), Adhan Pilon (Author), Nuno Mendes (Author), Ana Sofia Ribeiro (Author), Tiago D. Martins (Author), José Paulo S. Farinha (Author), M. Conceição Oliveira (Author), Fátima Gärtner (Author), M. Helena Garcia (Author), Ana Preto (Author), Andreia Valente (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The need for new therapeutic approaches for triple-negative breast cancer is a clinically relevant problem that needs to be solved. Using a multi-targeting approach to enhance cancer cell uptake, we synthesized a new family of ruthenium(II) organometallic complexes envisaging simultaneous active and...