Substantial uneven proliferation of CD4+ T cells during recovery from acute HIV infection is sufficient to explain the observed expanded clones in the HIV reservoir

Substantial uneven proliferation of CD4+ T cells during recovery from acute HIV infection is sufficient to explain the observed expanded clones in the HIV reservoir

The HIV reservoir is a population of 1-10 million anatomically dispersed, latently infected memory CD4+ T cells in which HIV DNA is quiescently integrated into human chromosomal DNA. When antiretroviral therapy (ART) is stopped and HIV replication initiates in one of these cells, systemic viral spre...

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Main Authors: Florencia A. Tettamanti Boshier (Author), Daniel B. Reeves (Author), Elizabeth R. Duke (Author), David A. Swan (Author), Martin Prlic (Author), E. Fabian Cardozo-Ojeda (Author), Joshua T. Schiffer (Author)
Format: Book
Published: Elsevier, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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