Substantial uneven proliferation of CD4+ T cells during recovery from acute HIV infection is sufficient to explain the observed expanded clones in the HIV reservoir

• المؤلفون الرئيسيون: Florencia A. Tettamanti Boshier (مؤلف), Daniel B. Reeves (مؤلف), Elizabeth R. Duke (مؤلف), David A. Swan (مؤلف), Martin Prlic (مؤلف), E. Fabian Cardozo-Ojeda (مؤلف), Joshua T. Schiffer (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2022-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The HIV reservoir is a population of 1-10 million anatomically dispersed, latently infected memory CD4+ T cells in which HIV DNA is quiescently integrated into human chromosomal DNA. When antiretroviral therapy (ART) is stopped and HIV replication initiates in one of these cells, systemic viral spre...