Synthesis of sericin-based conjugates by click chemistry: enhancement of sunitinib bioavailability and cell membrane permeation

• Main Authors: Luca Scrivano (Author), Domenico Iacopetta (Author), Maria Stefania Sinicropi (Author), Carmela Saturnino (Author), Pasquale Longo (Author), Ortensia Ilaria Parisi (Author), Francesco Puoci (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sericin is a natural protein that has been used in biomedical and pharmaceutical fields as raw material for polypeptide-based drug delivery systems (DDSs). In this paper, it has been employed as pharmaceutical biopolymer for the production of sunitinib-polypeptide conjugate. The synthesis has been c...