Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis
Mice are the most commonly used species for non-clinical evaluations of drug efficacy against tuberculosis (TB). Unlike commonly used strains, C3HeB/FeJ mice develop caseous necrosis in the lung, which might alter the representation of drug efficacy in a way that is more like human TB. Because the d...
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The Company of Biologists,
2015-06-01T00:00:00Z.
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