Metastable Reprogramming State of Single Transcription Factor-Derived Induced Hepatocyte-Like Cells

• Main Authors: Seon In Hwang (Author), Tae Hwan Kwak (Author), Ji Hyun Kang (Author), Jonghun Kim (Author), Hyunseong Lee (Author), Kee-Pyo Kim (Author), Kinarm Ko (Author), Hans R. Schöler (Author), Dong Wook Han (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously described the generation of induced hepatocyte-like cells (iHeps) using the hepatic transcription factor Hnf1a together with small molecules. These iHeps represent a hepatic state that is more mature compared with iHeps generated with multiple hepatic factors. However, the underlying m...