Targeted IgMs agonize ocular targets with extended vitreal exposure

• Main Authors: Yvonne Chen (Author), Maciej Paluch (Author), Julie A. Zorn (Author), Sharmila Rajan (Author), Brandon Leonard (Author), Alberto Estevez (Author), John Brady (Author), Henry Chiu (Author), Wilson Phung (Author), Amin Famili (Author), Minhong Yan (Author), Claudio Ciferri (Author), Marissa L. Matsumoto (Author), Greg A. Lazar (Author), Susan Crowell (Author), Phil Hass (Author), Nicholas J. Agard (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment of ocular disease is hindered by the presence of the blood-retinal barrier, which restricts access of systemic drugs to the eye. Intravitreal injections bypass this barrier, delivering high concentrations of drug to the targeted tissue. However, the recommended dosing interval for approved...