High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma

• Main Authors: Amrendra K. Ajay (Author), Philip Chu (Author), Poojan Patel (Author), Christa Deban (Author), Chitran Roychowdhury (Author), Radhika Heda (Author), Ahmad Halawi (Author), Anis Saad (Author), Nour Younis (Author), Hao Zhang (Author), Xiuju Jiang (Author), Mahmoud Nasr (Author), Li-Li Hsiao (Author), Gang Lin (Author), Jamil R. Azzi (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chordomas account for approximately 1-4% of all malignant bone tumors and 20% of primary tumors of the spinal column. It is a rare disease, with an incidence estimated to be approximately 1 per 1,000,000 people. The underlying causative mechanism of chordoma is unknown, which makes it challenging to...