Decreased TLR4 expression on monocytes may cause regulatory T cells abnormality in patients with primary immune thrombocytopenia

• Main Authors: Yating Hao (Author), Huiyuan Li (Author), Yang Li (Author), Mingen Lyu (Author), Donglei Zhang (Author), Rongfeng Fu (Author), Yue Guan (Author), Shixuan Wang (Author), Boyang Sun (Author), Xueqing Dou (Author), Renchi Yang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Primary immune thrombocytopenia (ITP) is an autoimmune disease with many immune dysfunctions including T helper type 1 cell (Th1) polarization and regulatory T cells (Tregs) deficiency. This study aimed to determine the effects of TLR4 on Treg differentiation and the cytokine production of periphera...