Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.

• Main Authors: Edézio Ferreira Cunha-Júnior (Author), Valter Viana Andrade-Neto (Author), Marta Lopes Lima (Author), Thais Alves da Costa-Silva (Author), Andres J Galisteo Junior (Author), Maria A Abengózar (Author), Coral Barbas (Author), Luis Rivas (Author), Elmo Eduardo Almeida-Amaral (Author), Andre Gustavo Tempone (Author), Eduardo Caio Torres-Santos (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The leishmanicidal action of tricyclic antidepressants has been studied and evidences have pointed that their action is linked to inhibition of trypanothione reductase, a key enzyme in the redox metabolism of pathogenic trypanosomes. Cyclobenzaprine (CBP) is a tricyclic structurally related to the a...