Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.

• Главные авторы: Edézio Ferreira Cunha-Júnior (Автор), Valter Viana Andrade-Neto (Автор), Marta Lopes Lima (Автор), Thais Alves da Costa-Silva (Автор), Andres J Galisteo Junior (Автор), Maria A Abengózar (Автор), Coral Barbas (Автор), Luis Rivas (Автор), Elmo Eduardo Almeida-Amaral (Автор), Andre Gustavo Tempone (Автор), Eduardo Caio Torres-Santos (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2017-01-01T00:00:00Z.
• Предметы: article
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The leishmanicidal action of tricyclic antidepressants has been studied and evidences have pointed that their action is linked to inhibition of trypanothione reductase, a key enzyme in the redox metabolism of pathogenic trypanosomes. Cyclobenzaprine (CBP) is a tricyclic structurally related to the a...