Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.

• Hoofdauteurs: Edézio Ferreira Cunha-Júnior (Auteur), Valter Viana Andrade-Neto (Auteur), Marta Lopes Lima (Auteur), Thais Alves da Costa-Silva (Auteur), Andres J Galisteo Junior (Auteur), Maria A Abengózar (Auteur), Coral Barbas (Auteur), Luis Rivas (Auteur), Elmo Eduardo Almeida-Amaral (Auteur), Andre Gustavo Tempone (Auteur), Eduardo Caio Torres-Santos (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2017-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The leishmanicidal action of tricyclic antidepressants has been studied and evidences have pointed that their action is linked to inhibition of trypanothione reductase, a key enzyme in the redox metabolism of pathogenic trypanosomes. Cyclobenzaprine (CBP) is a tricyclic structurally related to the a...