Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance

• Main Authors: Timo eKorjamo (Author), Ari eTolonen (Author), Veli-Pekka eRanta (Author), Miia eTurpeinen (Author), Hannu eKokki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxycodone is commonly used to treat severe pain in adults and children. It is extensively metabolized in the liver in adults, but the maturation of metabolism is not well understood. Our aim was to study the metabolism of oxycodone in cryopreserved human hepatocytes from different age groups (3 days...