RIPK3‐mediated cell death is involved in DUX4‐mediated toxicity in facioscapulohumeral dystrophy

• Main Authors: Virginie Mariot (Author), Romain Joubert (Author), Laura Le Gall (Author), Eva Sidlauskaite (Author), Christophe Hourde (Author), William Duddy (Author), Thomas Voit (Author), Maximilien Bencze (Author), Julie Dumonceaux (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Facioscapulohumeral dystrophy (FSHD) is caused by mutations leading to the aberrant expression of the DUX4 transcription factor in muscles. DUX4 was proposed to induce cell death, but the involvement of different death pathways is still discussed. A possible pro‐apoptotic role of...