Tetramisole is a new IK1 channel agonist and exerts IK1‐dependent cardioprotective effects in rats

• Main Authors: Qinghua Liu (Author), Jiaxing Sun (Author), Yangdou Dong (Author), Pan Li (Author), Jin Wang (Author), Yulan Wang (Author), Yanwu Xu (Author), Xinrui Tian (Author), Bowei Wu (Author), Peifeng He (Author), Qi Yu (Author), Xuechun Lu (Author), Jimin Cao (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cardiac ischemia, hypoxia, arrhythmias, and heart failure share the common electrophysiological changes featured by the elevation of intracellular Ca2+ (Ca2+ overload) and inhibition of the inward rectifier potassium (IK1) channel. IK1 channel agonists have been considered a new type of ant...