Application of ^99mTc-Labeled WL12 Peptides as a Tumor PD-L1-Targeted SPECT Imaging Agent: Kit Formulation, Preclinical Evaluation, and Study on the Influence of Coligands

• Principais autores: Mingxuan Fan (Autor), Jingjing Yao (Autor), Zuoquan Zhao (Autor), Xianzhong Zhang (Autor), Jie Lu (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2024-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

With the development of PD-1/PD-L1 immune checkpoint inhibitor therapy, the ability to monitor PD-L1 expression in the tumor microenvironment is important for guiding therapy. This study was performed to develop a novel radiotracer with optimal pharmacokinetic properties to reflect PD-L1 expression...