Succinylated whey protein isolate as a sustained-release excipient of puerarin derivative oral tablets: Preparation, optimization and pharmacokinetics

• Main Authors: Rui Zhang (Author), Yu Zhang (Author), Yue Wu (Author), Jun Liu (Author), Tiantian Ye (Author), Shujun Wang (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work was done to investigate succinylated commercial whey protein isolate (S-WPI) as an oral sustained-release delivery carrier for puerarin 5 (PR-5). The succinylation conditions were established for S-WPIs by optimization of single factor study and Box-Beehnken design. The effect of succinyla...