CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway

• Main Authors: Yujie Li (Author), Yufeng Zhang (Author), Hongshuo Shi (Author), Xuemei Liu (Author), Zifa Li (Author), Jiayi Zhang (Author), Xiuge Wang (Author), Wenbo Wang (Author), Xiaolin Tong (Author)
• Format: Book
• Published: BMC, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Epithelial-mesenchymal transition (EMT) plays a key role in tubulointerstitial fibrosis, which is a hallmark of diabetic kidney disease (DKD). Our previous studies showed that CRTC2 can simultaneously regulate glucose metabolism and lipid metabolism. However, it is still unclear...