The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability

• Main Authors: Limei Wang (Author), Veronika Palme (Author), Nicole Schilcher (Author), Angela Ladurner (Author), Elke H. Heiss (Author), Herbert Stangl (Author), Rudolf Bauer (Author), Verena M. Dirsch (Author), Atanas G. Atanasov (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report increased cholesterol efflux from macrophages in the presence of falcarindiol, an important dietary constituent present in commonly used vegetables and medicinal plants. Falcarindiol (3-20 μM) increased cholesterol efflux from THP-1-derived macrophages. Western blot analysis showed an incr...