Aerosolized In Vivo 3D Localization of Nose-to-Brain Nanocarrier Delivery Using Multimodality Neuroimaging in a Rat Model-Protocol Development

• Main Authors: Michael C. Veronesi (Author), Brian D. Graner (Author), Shih-Hsun Cheng (Author), Marta Zamora (Author), Hamideh Zarrinmayeh (Author), Chin-Tu Chen (Author), Sudip K. Das (Author), Michael W. Vannier (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The fate of intranasal aerosolized radiolabeled polymeric micellar nanoparticles (LPNPs) was tracked with positron emission tomography/computer tomography (PET/CT) imaging in a rat model to measure nose-to-brain delivery. A quantitative temporal and spatial testing protocol for new radio-nanotherano...