The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging.

• Main Authors: Manuel eRodriguez (Author), Ingrid eMorales (Author), Clara eRodriguez-Sabate (Author), Alberto eSanchez (Author), Rafael eCastro (Author), Jose Miguel eBrito (Author), Magdalena eSabate (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Available data show marked similarities for the degeneration of dopamine cells in Parkinson's disease and aging. The etio-pathogenic agents involved are very similar in both cases, and include free radicals, different mitochondrial disturbances, alterations of the mitophagy and the ubiquitin-pr...