Quantitative and histological assessment of maternal-fetal transmission of Trypanosoma cruzi in guinea pigs: An experimental model of congenital Chagas disease.

• Main Authors: Jatziri Torres-Vargas (Author), Matilde Jiménez-Coello (Author), Eugenia Guzmán-Marín (Author), Karla Y Acosta-Viana (Author), Zaida E Yadon (Author), Eduardo Gutiérrez-Blanco (Author), José Leonardo Guillermo-Cordero (Author), Nisha J Garg (Author), Antonio Ortega-Pacheco (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We evaluated the effect of Trypanosoma cruzi infection on fertility, gestation outcome, and maternal-fetal transmission in guinea pigs (Cavia porcellus).Animals were infected with T. cruzi H4 strain (TcI lineage) before gestation (IBG) or during gestation (IDG). Tissue and sera samples of dams and f...