Combination treatment of perifosine and valsartan showed more efficiency in protecting against pressure overload induced mouse heart failure

• Main Authors: Wen-jing Li (Author), Hai-han Liao (Author), Hong Feng (Author), Zi-ying Zhou (Author), Shan-qi Mou (Author), Nan Zhang (Author), Hai-ming Wu (Author), Hao Xia (Author), Qi-zhu Tang (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The optimum strategy for heart failure (HF) treatment has yet to be elucidated. This study intended to test the benefit of a combination of valsartan (VAL) and perifosine (PER), a specific AKT inhibitor, in protecting against pressure overload induced mouse HF. Mouse were subjected to aortic banding...