Liver Fibrosis Stages Affect Organic Cation Transporter 1/2 Activities in Hepatitis C Virus-Infected Patients

• Main Authors: Matheus De Lucca Thomaz (Author), Carolina Pinto Vieira (Author), Juciene Aparecida Caris (Author), Maria Paula Marques (Author), Adriana Rocha (Author), Tiago Antunes Paz (Author), Rosamar Eulira Fontes Rezende (Author), Vera Lucia Lanchote (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aims to evaluate the impact of liver fibrosis stages of chronic infection with hepatitis C virus (HCV) on the in vivo activity of organic cation transporters (hepatic OCT1 and renal OCT2) using metformin (MET) as a probe drug. Participants allocated in Group 1 (<i>n</i> = 15,...