The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512

• Main Authors: Hassan Mziaut (Author), Bernard Mulligan (Author), Peter Hoboth (Author), Oliver Otto (Author), Anna Ivanova (Author), Maik Herbig (Author), Desiree Schumann (Author), Tobias Hildebrandt (Author), Jaber Dehghany (Author), Anke Sönmez (Author), Carla Münster (Author), Michael Meyer-Hermann (Author), Jochen Guck (Author), Yannis Kalaidzidis (Author), Michele Solimena (Author)
• Format: Book
• Published: Elsevier, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin release from pancreatic islet β cells should be tightly controlled to avoid hypoglycemia and insulin resistance. The cortical actin cytoskeleton is a gate for regulated exocytosis of insulin secretory granules (SGs) by restricting their mobility and access to the plasma membrane....