Elucidation of the Molecular Mechanism and Exploration of Novel Therapeutics for Spinocerebellar Ataxia Caused by Mutant Protein Kinase Cγ

• Main Authors: Takahiro Seki (Author), Naoko Adachi (Author), Nana Abe-Seki (Author), Takayuki Shimahara (Author), Hideyuki Takahashi (Author), Kazuhiro Yamamoto (Author), Naoaki Saito (Author), Norio Sakai (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Spinocerebellar ataxia (SCA) is an inherited neurodegenerative disorder that is characterized by cerebellar atrophy and progressive ataxia and is classified into 31 types by the genetic locus. Recently, missense mutations of PRKCG genes that code protein kinase Cγ (γPKC) have been identif...