STAT4 targets KISS1 to promote the apoptosis of ovarian granulosa cells

• Main Authors: Yao Jiang (Author), Xiaoping Xin (Author), Xiangchun Pan (Author), Ailing Zhang (Author), Zhe Zhang (Author), Jiaqi Li (Author), Xiaolong Yuan (Author)
• Format: Book
• Published: BMC, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background In mammals, it is known that the estradiol-17β (E2) is mainly synthetized in ovarian granulosa cells (GCs), and the excessive apoptosis of GCs induces the follicular atresia. Many studies have implicated the essential role of KISS1, with the pro-synthetic effect of E2 and the ant...