A Novel Inhibitor of Homodimerization Targeting MyD88 Ameliorates Renal Interstitial Fibrosis by Counteracting TGF-β1-Induced EMT in Vivo and in Vitro

• Main Authors: Jian-Hua Liu (Author), Long He (Author), Zhi-Miao Zou (Author), Zuo-Chuan Ding (Author), Xue Zhang (Author), Hao Wang (Author), Ping Zhou (Author), Lin Xie (Author), Shuai Xing (Author), Cheng-Zhi Yi (Author)
• Format: Book
• Published: Karger Publishers, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: The TLR/MyD88/NF-κB signaling pathway has been successfully used to treat renal interstitial fibrosis (RIF). However, the exact therapeutic mechanism is still unknown. Here, we assessed the therapeutic efficacy of TJ-M2010-2, a small molecular compound that inhibits MyD88 homodimeri...