The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU
Once thought to be a waste product of oxygen limited (anaerobic) metabolism, lactate is now known to form continuously under fully oxygenated (aerobic) conditions. Lactate shuttling between producer (driver) and consumer cells fulfills at least 3 purposes; lactate is: (1) a major energy source, (2)...
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Elsevier,
2020-09-01T00:00:00Z.
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