Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100

• Main Authors: Víctor Toledano (Author), Enrique Hernández-Jiménez (Author), Carolina Cubillos-Zapata (Author), Marta Flandez (Author), Enrique Álvarez (Author), Aníbal Varela-Serrano (Author), Ramón Cantero (Author), Gema Valles (Author), Francisco García-Rio (Author), Eduardo López-Collazo (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of ac...