Inhibition of IL-10 and TGF-β receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells

• Autores principales: Chutamas Thepmalee (Autor), Aussara Panya (Autor), Mutita Junking (Autor), Thaweesak Chieochansin (Autor), Pa-thai Yenchitsomanus (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2018-06-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Tumor escapes host immune responses by producing immunosuppressive cytokines, such as IL-10 and TGF-β, secreted into the tumor microenvironment. These cytokines play important roles in the suppression of dendritic cell (DC) function, leading to decreased immune responses of the effector CD4+ and CD8...