Importance of Stability Analysis When Using Nonlinear Semimechanistic Models to Describe Drug‐Induced Hematotoxicity

• Main Authors: Chiara Fornari (Author), Carmen Pin (Author), James W.T. Yates (Author), Jerome T. Mettetal (Author), Teresa A. Collins (Author)
• 格式: 图书
• 出版: Wiley, 2020-09-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Stability analysis, often overlooked in pharmacometrics, is essential to explore dynamical systems. The model developed by Friberg et al.1 to describe drug‐induced hematotoxicity is widely used to support decisions across drug development, and parameter values are often identified from observed bloo...