Knock-Down of GPR88 in the Dorsal Striatum Alters the Response of Medium Spiny Neurons to the Loss of Dopamine Input and L-3-4-Dyhydroxyphenylalanine

• Main Authors: Manuela Ingallinesi (Author), Benjamin Galet (Author), Jonathan Pegon (Author), Nicole Faucon Biguet (Author), Anh Do Thi (Author), Mark J Millan (Author), Clotilde Mannoury la Cour (Author), Rolando Meloni (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effects of L-3-4-dyhydroxyphenylalanine (L-DOPA) treatment for replacing the dopamine (DA) loss in Parkinson's disease (PD) progressively wear off and are hindered by the development of dyskinesia, prompting the search for new treatments. The orphan G protein-coupled receptor 88 (Gpr88) rep...