Antileishmanial Activity and Inducible Nitric Oxide Synthase Activation by RuNO Complex

• Main Authors: Tatiane Marcusso Orsini (Author), Natalia Yoshie Kawakami (Author), Carolina Panis (Author), Ana Paula Fortes dos Santos Thomazelli (Author), Fernanda Tomiotto-Pellissier (Author), Allan Henrique Depieri Cataneo (Author), Danielle Kian (Author), Lucy Megumi Yamauchi (Author), Florêncio S. Gouveia Júnior (Author), Luiz Gonzaga de França Lopes (Author), Rubens Cecchini (Author), Idessânia Nazareth Costa (Author), Jean Jerley Nogueira da Silva (Author), Ivete Conchon-Costa (Author), Wander Rogério Pavanelli (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parasites of the genus Leishmania are capable of inhibiting effector functions of macrophages. These parasites have developed the adaptive ability to escape host defenses; for example, they inactivate the NF-κB complex and suppress iNOS expression in infected macrophages, which are responsible for t...