Rationalizing the Binding Modes of PET Radiotracers Targeting the Norepinephrine Transporter

• Main Authors: Anna Tutov (Author), Xinyu Chen (Author), Rudolf A. Werner (Author), Saskia Mühlig (Author), Thomas Zimmermann (Author), Naoko Nose (Author), Kazuhiro Koshino (Author), Constantin Lapa (Author), Michael Decker (Author), Takahiro Higuchi (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: A new PET radiotracer ¹⁸F-AF78 showing great potential for clinical application has been reported recently. It belongs to a new generation of phenethylguanidine-based norepinephrine transporter (NET)-targeting radiotracers. Although many efforts have been made to deve...