Extracellular HSP90α Interacts With ER Stress to Promote Fibroblasts Activation Through PI3K/AKT Pathway in Pulmonary Fibrosis

• Main Authors: Jinming Zhang (Author), Wenshan Zhong (Author), Yuanyuan Liu (Author), Weimou Chen (Author), Ye Lu (Author), Zhaojin Zeng (Author), Yujie Qiao (Author), Haohua Huang (Author), Xuan Wan (Author), Wei Li (Author), Xiaojing Meng (Author), Fei Zou (Author), Shaoxi Cai (Author), Hangming Dong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary fibrosis is characterized by alveolar epithelial cell injury, lung fibroblast proliferation, differentiation, and extracellular matrix (ECM) deposition. Our previous study indicated that extracellular HSP90α (eHSP90α) promotes pulmonary fibrosis by activating the MAPK signaling pathway. Th...