Evaluation of pharmacological and pharmacokinetic herb-drug interaction between irinotecan hydrochloride injection and Kangai injection in colorectal tumor-bearing mice and healthy rats

• Egile Nagusiak: Yanfei Chen (Egilea), Zhaoliang Hu (Egilea), Jing Jiang (Egilea), Chenxi Liu (Egilea), Shuxiao Gao (Egilea), Min Song (Egilea), Taijun Hang (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Introduction: Kangai (KA) injection, a Chinese herbal injection, is often used in combination with irinotecan (CPT-11) to enhance the effectiveness of anti-colorectal cancer treatment and alleviate side effects. However, the combined administration of this herb-drug pair remains controversial due to...