Termination of Aconitine-Induced Atrial Fibrillation by the KACh-Channel Blocker Tertiapin: Underlying Electrophysiological Mechanism

• Main Authors: Kazumasa Suzuki (Author), Akio Matsumoto (Author), Hirofumi Nishida (Author), Yoshie Reien (Author), Hiroo Maruyama (Author), Haruaki Nakaya (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: The acetylcholine receptor-operated K+ (KACh) channel may be a novel target for atrial-specific antiarrhythmic therapy. Recently it has been demonstrated that tertiapin, a selective blocker of KACh channel, suppressed aconitine-induced atrial fibrillation (AF) in dogs. However, the precis...