Termination of Aconitine-Induced Atrial Fibrillation by the KACh-Channel Blocker Tertiapin: Underlying Electrophysiological Mechanism

• Autori principali: Kazumasa Suzuki (Autore), Akio Matsumoto (Autore), Hirofumi Nishida (Autore), Yoshie Reien (Autore), Hiroo Maruyama (Autore), Haruaki Nakaya (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2014-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract.: The acetylcholine receptor-operated K+ (KACh) channel may be a novel target for atrial-specific antiarrhythmic therapy. Recently it has been demonstrated that tertiapin, a selective blocker of KACh channel, suppressed aconitine-induced atrial fibrillation (AF) in dogs. However, the precis...