Inhibition of adenylyl cyclase 1 by ST034307 inhibits IP3-evoked changes in sino-atrial node beat rate

• Main Authors: Samuel J. Bose (Author), Matthew J. Read (Author), Emily Akerman (Author), Rebecca A. Capel (Author), Thamali Ayagama (Author), Angela Russell (Author), Derek A. Terrar (Author), Manuela Zaccolo (Author), Rebecca A. B. Burton (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atrial arrhythmias, such as atrial fibrillation (AF), are a major mortality risk and a leading cause of stroke. The IP3 signalling pathway has been proposed as an atrial-specific target for AF therapy, and atrial IP3 signalling has been linked to the activation of calcium sensitive adenylyl cyclases...