A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation

• Main Authors: Jaime Chu (Author), Alexander Mir (Author), Ningguo Gao (Author), Sabrina Rosa (Author), Christopher Monson (Author), Vandana Sharma (Author), Richard Steet (Author), Hudson H. Freeze (Author), Mark A. Lehrman (Author), Kirsten C. Sadler (Author)
• Format: Book
• Published: The Company of Biologists, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Individuals with congenital disorders of glycosylation (CDG) have recessive mutations in genes required for protein N-glycosylation, resulting in multi-systemic disease. Despite the well-characterized biochemical consequences in these individuals, the underlying cellular defects that contrib...