m6A-induced repression of SIAH1 facilitates alternative splicing of androgen receptor variant 7 by regulating CPSF1

• Main Authors: Lei Xia (Author), Qing Han (Author), Xuehui Duan (Author), Yinjie Zhu (Author), Jiahua Pan (Author), Baijun Dong (Author), Weiliang Xia (Author), Wei Xue (Author), Jianjun Sha (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Androgen receptor splice variant 7 (AR-v7), a constitutively active transcription factor, plays a crucial role in the progression of castration-resistant prostate cancer (CRPC). Here, we found that the cleavage and polyadenylation specificity factor 1 (CPSF1) (the largest subunit of the multi-protei...