Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance

• Main Authors: Alessia Fidoamore (Author), Loredana Cristiano (Author), Andrea Antonosante (Author), Michele d'Angelo (Author), Erica Di Giacomo (Author), Carlo Astarita (Author), Antonio Giordano (Author), Rodolfo Ippoliti (Author), Elisabetta Benedetti (Author), Annamaria Cimini (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among all solid tumors, the high-grade glioma appears to be the most vascularized one. In fact, "microvascular hyperplasia" is a hallmark of GBM. An altered vascular network determines irregular blood flow, so that tumor cells spread rapidly beyond the diffusion distance of oxygen in the t...