Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function

• Main Authors: Frank Elbers (Author), Claudia Woite (Author), Valentina Antoni (Author), Sara Stein (Author), Hiroshi Funakoshi (Author), Toshikazu Nakamura (Author), Gereon Schares (Author), Walter Däubener (Author), Silvia K. Eller (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tryptophan is an essential amino acid for hosts and pathogens. The liver enzyme tryptophan 2,3-dioxygenase (TDO) provokes, by its ability to degrade tryptophan to N-formylkynurenine, the precursor of the immune-relevant kynurenines, direct and indirect antimicrobial and immunoregulatory states. Up t...