Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function

• Egile Nagusiak: Frank Elbers (Egilea), Claudia Woite (Egilea), Valentina Antoni (Egilea), Sara Stein (Egilea), Hiroshi Funakoshi (Egilea), Toshikazu Nakamura (Egilea), Gereon Schares (Egilea), Walter Däubener (Egilea), Silvia K. Eller (Egilea)
• Formatua: Liburua
• Argitaratua: Hindawi Limited, 2016-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Tryptophan is an essential amino acid for hosts and pathogens. The liver enzyme tryptophan 2,3-dioxygenase (TDO) provokes, by its ability to degrade tryptophan to N-formylkynurenine, the precursor of the immune-relevant kynurenines, direct and indirect antimicrobial and immunoregulatory states. Up t...