Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function
Tryptophan is an essential amino acid for hosts and pathogens. The liver enzyme tryptophan 2,3-dioxygenase (TDO) provokes, by its ability to degrade tryptophan to N-formylkynurenine, the precursor of the immune-relevant kynurenines, direct and indirect antimicrobial and immunoregulatory states. Up t...
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2016-01-01T00:00:00Z.
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