Genome-wide association study for Chagas Cardiomyopathy identify a new risk locus on chromosome 18 associated with an immune-related protein and transcriptional signature.

Genome-wide association study for Chagas Cardiomyopathy identify a new risk locus on chromosome 18 associated with an immune-related protein and transcriptional signature.

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<h4>Background</h4>Chronic Chagas Cardiomyopathy (CCC) usually develops between 10 and 20 years after the first parasitic infection and is one of the leading causes of end-stage heart failure in Latin America. Despite the great inter-individual variability in CCC susceptibility (only 30%...

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Main Authors: Ester Cerdeira Sabino (Author), Lucas Augusto Moysés Franco (Author), Gabriela Venturini (Author), Mariliza Velho Rodrigues (Author), Emanuelle Marques (Author), Lea Campos de Oliveira-da Silva (Author), Larissa Natany Almeida Martins (Author), Ariela Mota Ferreira (Author), Paulo Emílio Clementino Almeida (Author), Felipe Dias Da Silva (Author), Sâmara Fernandes Leite (Author), Maria do Carmo Pereira Nunes (Author), Desiree Sant'Ana Haikal (Author), Claudia Di Lorenzo Oliveira (Author), Clareci Silva Cardoso (Author), Jonathan G Seidman (Author), Christine E Seidman (Author), Juan P Casas (Author), Antonio Luiz Pinho Ribeiro (Author), Jose E Krieger (Author), Alexandre C Pereira (Author)
Format: Book
Published: Public Library of Science (PLoS), 2022-10-01T00:00:00Z.
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