Solubility enhancement of benfotiamine, a lipid derivative of thiamine by solid dispersion technique

• Asıl Yazarlar: S M Patel (Yazar), R P Patel (Yazar), B G Prajapati (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wolters Kluwer Medknow Publications, 2012-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The present study was aimed to increase the solubility of the poorly water soluble drug benfotiamine using hydrophilic polymers (PVP K-30 and HPMC E4). Solid dispersions were prepared by kneading method. Phase solubility study, in-vitro dissolution of pure drug, physical mixtures and solid dispersio...