Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design

• Main Authors: Makarand Suresh Gambhire (Author), Mangesh Ramesh Bhalekar (Author), Vaishali Makarand Gambhire (Author)
• Format: Bog
• Udgivet: Universidade de São Paulo, 2011-09-01T00:00:00Z.
• Fag: article
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This study describes a 3² full factorial experimental design to optimize the formulation of dithranol (DTH) loaded solid lipid nanoparticles (SLN) by the pre-emulsion ultrasonication method. The variables drug: lipid ratio and sonication time were studied at three levels and arranged in a 3² factori...