Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design

• Autori principali: Makarand Suresh Gambhire (Autore), Mangesh Ramesh Bhalekar (Autore), Vaishali Makarand Gambhire (Autore)
• Natura: Libro
• Pubblicazione: Universidade de São Paulo, 2011-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

This study describes a 3² full factorial experimental design to optimize the formulation of dithranol (DTH) loaded solid lipid nanoparticles (SLN) by the pre-emulsion ultrasonication method. The variables drug: lipid ratio and sonication time were studied at three levels and arranged in a 3² factori...