The Novel Cognitive Enhancer ST101 Enhances Acetylcholine Release in Mouse Dorsal Hippocampus Through T-type Voltage-Gated Calcium Channel Stimulation

• Autors principals: Yui Yamamoto (Autor), Norifumi Shioda (Autor), Feng Han (Autor), Shigeki Moriguchi (Autor), Kohji Fukunaga (Autor)
• Format: Llibre
• Publicat: Elsevier, 2013-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

We recently developed a novel cognitive enhancer, ST101 (spiro[imidazo[1,2-a] pyridine-3,2-indan]-2(3H)-one), that activates T-type voltage-gated calcium channels (VGCCs). Here, we address whether T-type VGCC activation with ST101 mediates its cognitive effects in vivo and the relevance of T-type VG...