Freeze-Dried Mesenchymal Stem Cell-Secretome Pharmaceuticalization: Optimization of Formulation and Manufacturing Process Robustness

• Main Authors: Michela Mocchi (Author), Elia Bari (Author), Giorgio Marrubini (Author), Andrea Foglio Bonda (Author), Sara Perteghella (Author), Fulvio Tartara (Author), Fabio Cofano (Author), Giuseppe di Perna (Author), Lorella Giovannelli (Author), Delia Mandracchia (Author), Marzio Sorlini (Author), Diego Garbossa (Author), Maria Luisa Torre (Author), Lorena Segale (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Producing mesenchymal stem cell (MSC)-secretome for dose escalation studies and clinical practice requires scalable and good manufacturing practice (GMP)-compliant production procedures and formulation into a standardized medicinal product. Starting from a method that combines ultrafiltration and fr...